VICP Registry Case Source Bundle Canonical URL: https://vicp-registry.org/case/USCOURTS-cofc-1_15-vv-00519 Package ID: USCOURTS-cofc-1_15-vv-00519 Petitioner: Jeremy Eamick Filed: 2015-05-21 Decided: 2019-07-24 Vaccine: hepatitis A Vaccination date: 2012-07-17 Condition: Miller-Fisher variant of Guillain-Barré syndrome Outcome: compensated Award amount USD: 1217984 AI-assisted case summary: Jeremy Eamick filed a petition for compensation under the National Vaccine Injury Compensation Program on May 21, 2015, alleging that the hepatitis A and hepatitis B vaccines he received caused him to develop the Miller-Fisher variant of Guillain-Barré syndrome (GBS). Mr. Eamick was 33 years old at the time. He had received multiple vaccines on June 15, 2012, including hepatitis A and B, and received a second dose of hepatitis A and B vaccines on July 17, 2012. He also experienced an upper respiratory infection (URI) in the month preceding the onset of his GBS symptoms, which first manifested on July 24, 2012. The Special Master's Ruling on Entitlement, issued on May 15, 2018, found that while the URI was a but-for cause of Mr. Eamick's GBS, the hepatitis vaccines were also a substantial factor. Petitioner's expert, Dr. Eric Gershwin, proposed a theory that the cytokine response from the hepatitis vaccines interacted with the immune response to the URI, leading to a loss of tolerance and GBS. Respondent's expert, Dr. Penelope Morel, argued that the URI alone was sufficient to cause the GBS. The Special Master found Dr. Gershwin's theory persuasive and the temporal relationship between the vaccination and the onset of GBS to be appropriate, satisfying the criteria outlined in Althen v. Secretary of Health & Human Services. The Special Master concluded that Mr. Eamick had met his burden of proof for an off-Table injury and was entitled to compensation. Following the entitlement ruling, the parties stipulated to an award of damages. On July 24, 2019, Special Master Christian J. Moran issued a decision awarding Mr. Eamick $1,217,984.83. This award included a lump sum payment of $1,217,984.83 for life care expenses incurred in the first year, lost earnings, pain and suffering, and past unreimbursable expenses. Additionally, an amount sufficient to purchase an annuity contract was awarded to cover future life care items, with specified growth rates for medical and non-medical expenses. The annuity payments were to be made to Mr. Eamick for his lifetime. Petitioner was represented by Edward M. Kraus of the Law Offices of Chicago Kent, and respondent was represented by Lisa Ann Watts of the U.S. Department of Justice. Theory of causation field: Petitioner Jeremy Eamick, age 33, received hepatitis A and B vaccines on June 15, 2012, and July 17, 2012, and subsequently developed Guillain-Barré syndrome (GBS), specifically the Miller-Fisher variant. He also had a preceding upper respiratory infection (URI). Petitioner's expert, Dr. Eric Gershwin, proposed a theory that the cytokine response from the hepatitis vaccines, acting on lymph nodes where the URI immune response was also occurring, caused a loss of tolerance through molecular mimicry, leading to GBS. Respondent's expert, Dr. Penelope Morel, contended that the URI was the sole substantial factor. The Special Master, Christian J. Moran, found Dr. Gershwin's theory persuasive and the temporal relationship appropriate, concluding that the vaccines were a substantial factor in causing the GBS, an off-Table injury. The parties stipulated to an award of $1,217,984.83, comprising a lump sum for first-year life care expenses, lost earnings, pain and suffering, and past unreimbursable expenses, plus an annuity for future life care items. Attorneys for petitioner were Edward M. Kraus and for respondent was Lisa Ann Watts. The entitlement ruling was dated May 15, 2018, and the damages award was dated July 24, 2019. Public staged source text: ================================================================================ DOCUMENT 1: USCOURTS-cofc-1_15-vv-00519-0 Date issued/filed: 2018-06-12 Pages: 13 Docket text: PUBLIC ORDER/RULING (Originally filed: 5/15/2018) regarding 71 Ruling on Entitlement. Signed by Special Master Christian J. Moran. (abs) Service on parties made. -------------------------------------------------------------------------------- Case 1:15-vv-00519-UNJ Document 73 Filed 06/12/18 Page 1 of 13 In the United States Court of Federal Claims OFFICE OF SPECIAL MASTERS * * * * * * * * * * * * * * * * * * * * * JEREMY EAMICK, * * Petitioner, * No. 15-519V * Special Master Christian J. Moran v. * * Filed: May 15, 2018 SECRETARY OF HEALTH * AND HUMAN SERVICES, * Entitlement, hepatitis A vaccine, * hepatitis B vaccine, GBS, cytokines, Respondent. * concurrent illness. * * * * * * * * * * * * * * * * * * * * * Edward M. Kraus, Law Offices of Chicago Kent, Chicago, IL, for petitioner; Lisa Ann Watts, United States Dep’t of Justice, Washington, DC, for respondent. RULING ON ENTITLEMENT1 Petitioner, Jeremy Eamick, alleges that the hepatitis A and hepatitis B vaccines that he received on June 15, 2012 and July 17, 2012, caused him to develop the Miller-Fisher variant of Guillain-Barré syndrome (“GBS”).2 Mr. Eamick is seeking compensation pursuant to the National Childhood Vaccine Injury Compensation Program, codified at 42 U.S.C. § 300aa−10 through 34 (2012). The parties do not dispute that an upper respiratory infection (“URI”) affecting Mr. Eamick in the month leading to the onset of his GBS was a but-for 1 The E-Government Act, 44 U.S.C. § 3501 note (2012) (Federal Management and Promotion of Electronic Government Services), requires that the Court post this decision on its website. Pursuant to Vaccine Rule 18(b), the parties have 14 days to file a motion proposing redaction of medical information or other information described in 42 U.S.C. § 300aa-12(d)(4). Any redactions ordered by the special master will appear in the document posted on the website. 2 Miller-Fisher syndrome is a variant of GBS that is found in a small subset of the United States GBS population. Tr. 72, 101. For the purposes here, Mr. Eamick’s condition is referred to as GBS since, according to petitioner, the fact that his GBS was of the Miller-Fisher variant is not important to his theory of causation. Tr. 73, 76. 1 Case 1:15-vv-00519-UNJ Document 73 Filed 06/12/18 Page 2 of 13 cause of his GBS. However, petitioner’s expert, Dr. Eric Gershwin, adds that the infection was not sufficient to cause Mr. Eamick to develop GBS and that it was the vaccines that transformed the relatively ubiquitous URI into an infection that ultimately caused Mr. Eamick to develop GBS. Respondent’s expert, Dr. Penelope Morel, disagrees. She argues that Mr. Eamick’s URI was sufficient to cause his GBS. Under the framework for determining causation promulgated by the Federal Circuit, Mr. Eamick has met his burden for proving entitlement to compensation. Mr. Eamick presents a logical sequence of cause and effect connecting the vaccination and the injury, which is based on a persuasive medical theory and a showing that the temporal sequence is appropriate. Further, the Secretary has not established that a factor unrelated to the vaccination is the cause of Mr. Eamick’s symptoms. I. Facts The facts of Mr. Eamick’s case are not in dispute. Mr. Eamick was 33 years old when he developed GBS in July 2012. The month before, Mr. Eamick reported for basic training in the Army National Guard. Exhibit 1 at 6. As part of his service, Mr. Eamick received vaccines for adenovirus 4 and 7, bicillin, hepatitis A and hepatitis B, meningococcal, polio IPV, and tetanus-diphtheria-pertussis on June 15, 2012. Exhibit 11 at 1. Three weeks later, on July 7, 2012, Mr. Eamick went to the clinic with complaints of congestion, cough, and sinus discharge. Exhibit 8 at 54. Ten days following this visit, on July 17, 2012, Mr. Eamick was vaccinated again with the second administration of the hepatitis A and hepatitis B vaccines. Exhibit 11 at 1. During this time, Mr. Eamick’s respiratory infection had been progressively worsening and he reported to the clinic again on July 21, 2012. Exhibit 8 at 50. At this visit, he was diagnosed with bronchitis and was prescribed an antibiotic. Id. Dr. Gershwin and Dr. Morel agree that Mr. Eamick’s GBS first manifested on July 24, 2012. Tr. 108, 200. On that date, he went to the emergency department at Fort Leonard Wood Hospital complaining of difficulty speaking, difficulty with coordination, and numbness in his face, hands, and feet. Exhibit 1 at 39. He was discharged and ordered to bed rest. Id. at 43. He returned to the same hospital the next day when he had difficulty walking and performing his duties. Id. at 44-45. The hospital diagnosed him with an acute neurological injury. Exhibit 8 at 7. The hospital also recommended that Mr. Eamick be sent to the 2 Case 1:15-vv-00519-UNJ Document 73 Filed 06/12/18 Page 3 of 13 University of Missouri Hospital, which he was later that same day, July 25, 2012. Id.; exhibit 1 at 53. Mr. Eamick was hospitalized at the University of Missouri hospital for longer than two weeks. See exhibit 2. Testing found anti-GQ1b antibodies, which confirmed a diagnosis of GBS.3 Id. at 68. Although Mr. Eamick received extensive care, including plasmapheresis and physical therapy, he continues to experience disability due to the GBS. See exhibit 12 at 1-5. Both experts characterized Mr. Eamick’s case to be a particularly severe form of GBS. Tr. 96, 184. Mr. Eamick filed his petition for compensation on May 21, 2015. On November 4, 2015, respondent filed his Rule 4(c) report, stating that there was, among other deficits, insufficient evidence linking vaccinations to GBS. See Resp’t’s Rep., filed Nov. 4, 2015, at 7-10. Mr. Eamick filed two reports from Dr. Gershwin in support of his claim for compensation (exhibits 25 and 113). The Secretary filed two responsive reports from Dr. Morel (exhibits B and DD).4 A one-day entitlement hearing was held on September 13, 2017. Mr. Eamick, Dr. Gershwin, and Dr. Morel testified in the hearing. II. The Experts’ Qualifications and Assessment A. Dr. Eric Gershwin, M.D. Dr. Gershwin is a Distinguished Professor of Medicine with the University of California at Davis, where he currently holds a chaired professorship in honor of Jack and Donald Chia. Dr. Gershwin received his undergraduate degree, summa cum laude, from Syracuse University and his medical degree from Stanford. He has an honorary doctorate from the University of Athens, in recognition for his lifetime contribution in immunology and medicine. He has also been awarded the AESKU prize in Autoimmunity in 2008, in recognition of his lifetime contribution in immunology. He is also fellow with the American Association for the Advancement of Science. He is board-certified in internal medicine, rheumatology, and allergy and clinical immunology, and currently serves as the 3 See generally exhibit 58 for a discussion of how antibodies to gangliosides (molecular structures present on neurons)—such as GQ1b—mediate the course of GBS. 4 Ancillary reports from the experts addressing specific questions were also filed by both petitioner and respondent. 3 Case 1:15-vv-00519-UNJ Document 73 Filed 06/12/18 Page 4 of 13 editor-in-chief for the Journal of Autoimmunity, Autoimmunity Reviews, and Clinical Reviews in Allergy. He has written or edited 68 books or monographs, approximately 1,000 experimental research articles, 160 book chapters, and 200 review articles. B. Dr. Penelope Morel, M.D. Dr. Morel is a professor in the Department of Immunology at the University of Pittsburgh, with a secondary appointment as a professor in the Department of Medicine. She also serves as an affiliate member in the Center for Vaccine Research. Dr. Morel received her undergraduate and medical degrees from the University of Southampton in the United Kingdom. She obtained her doctor of medicine in immunology from the University of Geneva in Switzerland. While she performed clinical work early in her career, she no longer practices medicine and does not hold any board certifications. Tr. 176. Dr. Morel has published approximately 70 experimental research articles, and 40 non-experimental articles, chapters, and reviews. C. Evaluation In considering the value of opinion testimony, special masters may consider the offeror's expertise and weigh the opinion accordingly. Copenhaver v. Sec'y of Health & Human Servs., No. 13-1002V, 2016 WL 3456436, at *7 (Fed. Cl. Spec. Mstr. May 31, 2016), mot. for rev. denied, 129 Fed. Cl. 176 (2016). Beyond expertise, special masters may make determinations as to the credibility of the persons presenting opinion evidence. Moberly v. Sec'y of Health & Human Servs., 592 F.3d 1315, 1326 (Fed. Cir. 2010). While both experts provided helpful testimony, Dr. Gershwin’s testimony was considerably more impressive. Dr. Gershwin’s testimony struck the undersigned as being highly credible. He appeared confident in the opinions he did express, but at the same time he was candid and forthright when stating the limits of those opinions and the stochastic nature of topics being discussed. In addition, Dr. Gershwin’s experience and expertise as both a physician and a scientist allowed him to provide helpful insight into the questions at issue. Finally, Dr. Gershwin’s scholarship is broad; few experts in the Vaccine Program have written as prodigiously as he has. His expansive knowledge in the field of autoimmunity gave substantial weight to his opinions. 4 Case 1:15-vv-00519-UNJ Document 73 Filed 06/12/18 Page 5 of 13 Compared to Dr. Gershwin, Dr. Morel’s answers were often uncertain in both tone and content. While Dr. Morel is medically trained, she has not treated patients in some time and this lack of practical experience, accordingly, limited the weight and scope of some of her opinions. While Dr. Morel’s scholarship is impressive, the scope of her scholarship and reputability in the field of immunology has not yet reached the level of Dr. Gershwin. This may very well reflect that she is at an earlier stage of her career compared to Dr. Gershwin, but that does not affect the ultimate impression that Dr. Gershwin’s opinion carries with it more weight on topics in immunology. III. Standards for Adjudication Compensation under the Vaccine Act is available in two major forms. Table injuries, which presume causation, can be established if a prescribed injury occurs during a set period of time following a specific vaccination. 42 U.S.C. § 300aa- 11(c)(1)(C)(i). Alternatively, petitioners can receive compensation for injuries not provided for in the Vaccine Injury Table by bringing a successful petition for compensation under 42 U.S.C. § 300aa-11(c)(1)(C)(ii) of the Vaccine Act. Here, Mr. Eamick does not claim that GBS constitutes a Table injury for hepatitis A or B vaccine under the Vaccine Act. As an “off-Table Injury,” Mr. Eamick must demonstrate that the vaccination caused his injury. Petitioner’s burden of proof as an off-Table injury is explicitly defined by Congress. The Act provides that a petitioner must show, by a preponderance of the evidence, that the vaccination caused or significantly aggravated his illness or injury. See 42 U.S.C. § 300aa–13(a)(1) and 42 U.S.C. § 300aa-11(c); see also Moberly, 592 F.3d at 1322 (noting that petitioners must prove causation by the traditional tort standard of preponderance). As for what is specifically required to meet this burden, the statute requires that the conclusion of the court or special master may not be “based on the claims of a petitioner alone, unsubstantiated by medical records or by medical opinion.” 42 U.S.C. § 300aa-13(a)(1). The statute does not speak to the strength or reputability of the medical opinion, just that a medical opinion or medical records are necessary for a claim to be meritorious. See id. In drawing conclusions on causation, the Federal Circuit has noted that special masters must be careful not to raise petitioners’ burden by establishing tests that create requirements not in the statute itself. Capizzano v. Sec'y of Health & Human Servs., 440 F.3d 1317, 1325 (Fed. Cir. 2006) (rejecting a test that required 5 Case 1:15-vv-00519-UNJ Document 73 Filed 06/12/18 Page 6 of 13 “epidemiologic studies, rechallenge, the presence of pathological markers or genetic disposition, or general acceptance in the scientific or medical communities”); Althen v. Sec'y of Health & Human Servs., 418 F.3d 1274, 1279 (Fed. Cir. 2005) (rejecting a test requiring “confirmation of medical plausibility from the medical community and literature” to prove causation in fact); Knudsen v. Sec'y of Health & Human Servs., 35 F.3d 543, 549 (Fed. Cir. 1994) (“to require identification and proof of specific biological mechanisms would be inconsistent with the purpose and nature of the vaccine compensation program”). Instead, special masters must consider all the evidence and decide whether the causal link between the vaccination and the injury was logical and legally probable. See Knudsen, 35 F.3d at 549 (“The sole issues for the special master are, based on the record evidence as a whole and the totality of the case, whether it has been shown by a preponderance of the evidence that a vaccine caused the [] injury.”); Grant v. Sec’y of Health & Human Servs., 956 F.2d 1144, 1148 (Fed. Cir. 1992) (“Causation in fact requires proof of a logical sequence of cause and effect showing that the vaccination was the reason for the injury.”); Hines v. Sec'y of Health & Human Servs., 940 F.2d 1518, 1525 (Fed. Cir. 1991) (“causation in fact requires proof of a logical sequence of cause and effect showing that the vaccination was the reason for the injury.”). In determining whether preponderant evidence exists, the Federal Circuit has set forth a three-part framework for evaluating claims of vaccine injury causation. As explained in Althen, and subsequent opinions, petitioners must put forth: “(1) a medical theory causally connecting the vaccination and the injury; (2) a logical sequence of cause and effect showing that the vaccination was the reason for the injury; and (3) a showing of a proximate temporal relationship between vaccination and injury.” Althen, 418 F.3d at 1278. IV. Analysis A. Althen Prong One: Petitioner’s Medical Theory. Mr. Eamick does not need to prove with scientific certainty that the vaccination he received can cause GBS. However, petitioners may not posit just any theory of causation; the theory must be “reputable.” Althen, 418 F.3d at 1278 (“A persuasive medical theory . . . being supported by reputable medical or scientific explanation”) (internal citations omitted). What makes a theory “reputable” is not exactly clear. In Hibbard, the Federal Circuit stated that petitioner’s burden was to provide a “viable medical theory by which a vaccine can cause the injury claimed by the petitioner.” Hibbard v. Sec'y of Health & Human 6 Case 1:15-vv-00519-UNJ Document 73 Filed 06/12/18 Page 7 of 13 Servs., 698 F.3d 1355, 1365 (Fed. Cir. 2012). In contrast to mere “viability,” in Moberly, the Federal Circuit required that the theory be “legally probable.” Moberly v. Sec'y of Health & Human Servs., 592 F.3d 1315, 1322 (Fed. Cir. 2010). Though the Federal Circuit has not spoken in unison about what exactly is required from petitioners, based on the directives it has provided, it appears accurate to say that petitioner’s medical theory linking the vaccination and the injury must, at the least, be consistent with what is known about human biology. Without a theory that passes that barrier, the Federal Circuit dictates that compensation should be precluded. If the theory meets this minimum barrier to entry, the special master should proceed to consider the other Althen elements to make an ultimate conclusion on the question of whether predominant evidence exists to find causation. To understand the experts’ positions as it relates to Mr. Eamick’s case, a brief review of Mr. Eamick’s condition and its etiology is useful. GBS is a potentially life-threatening disease hallmarked by weakness in the extremities. Exhibit E at 1. Some cases, as in Mr. Eamick’s, result in respiratory distress. Id. Scientists believe that GBS is autoimmune in nature and results from the body’s immune system generating crossreactive antibodies formed in response to pathogen-borne antigens. See id. at 1-4. These antibodies will then attack nerve membranes, resulting in nerve damage or a loss of nerve conduction. Id. This attack on the body’s own cells is referred to as a “loss of tolerance.” As noted before, the creation of the cross-reactive antibodies is usually the result of exposure to certain pathogens. Id. at 3. Some pathogens will result in GBS more frequently than others. Id. Although the most common is Campylobacter jejuni, a gastrointestinal infection, upper respiratory infections, such as the infection that Mr. Eamick had, are another common culprit. Id. It is not known why some URIs develop into GBS while most do not. Dr. Gershwin cites from exhibit 51 (Hadden) for the proposition that the reason some infections result in GBS is likely a function of how the body’s immune system responds to the infection as opposed to features of the infection itself. Tr. 82. Specifically, he references the authors’ statement that “[t]he pathogenesis is likely to depend not only on the immunogenic components of the infecting organisms, but also on the host's immune response." Id. (referencing exhibit 51 (R.D.M. Hadden et al., Preceding Infections, Immune Factors, And Outcome In Guillain- Barre Syndrome, 56 Neurology 758 (2001)) at 7). Importantly, Dr. Morel, agreed with this proposition in her testimony. See Tr. 247-48. 7 Case 1:15-vv-00519-UNJ Document 73 Filed 06/12/18 Page 8 of 13 Dr. Gershwin, in his reports and his testimony, provided a persuasive case for how the hepatitis vaccines could dysregulate the host’s response to the URI infection in a way that resulted in a breach of tolerance. Dr. Gershwin argued that cytokines are already known to act as “amplifiers” that “facilitate antigen presentation” by “augmenting . . . antibody production.” Tr. 76-77. This cytokine response plays a necessary role in developing Mr. Eamick’s immune response to the URI. A similar type of cytokine response happens as a result of all vaccinations. Tr. 88. In Dr. Gershwin’s estimation, this cytokine response from the vaccination can have non-specific effects. Specifically, it can, in conjunction with the immune response to the URI, result in a loss of tolerance to endogenous antigens through molecular imitation of the URI antigen. Tr. 85, 89. This crossreactivity is what ultimately leads to GBS. Tr. 89. The Secretary’s expert, Dr. Morel, attempted to rebut Dr. Gershwin’s theory on three main grounds. First, she argues that the cytokine response to the vaccine could not have interacted with the response to the URI since the cytokine response to the vaccine is limited in space and does not result in a systemic cytokine response. Tr. 188. Second, she argues that the epidemiological evidence does not support causation. Third, she argues that there is no evidence in support of Dr. Gershwin’s theory. Tr. 183-84. These critiques are addressed in turn. Dr. Morel argues that “there would have to have been some evidence of some widespread systemic response to the vaccine in order to really believe that this response would have spilled over and caused further exacerbation of what was already an immune response to a quite severe respiratory infection.” Tr. 189-90. While Dr. Gershwin disagrees with Dr. Morel’s statement that the cytokine reaction to the vaccine is not systemic, Tr. 91, he ultimately states that the issue of the systematic nature of the immune response is moot. He argues that since the lymph nodes where the cytokine response to the vaccine would occur are the same as the lymph nodes where the immune response to the URI would occur, the two responses have the opportunity to interact. Tr. 91-92. Dr. Morel does not challenge that there is a strong cytokine response to the vaccine in the lymph nodes, Tr. 190, and actually proffers exhibit HH to make that very point. See exhibit FF at 2 (citing exhibit HH (Nikolaos Chatziandreou, Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node, 18 Cell Reports 2427 (2017)) to establish that “the majority of the cytokines produced by cells of the innate and adaptive immune system are confined to the lymph node”). 8 Case 1:15-vv-00519-UNJ Document 73 Filed 06/12/18 Page 9 of 13 While Dr. Morel did introduce persuasive epidemiological studies showing that there is not an association between hepatitis vaccines and GBS, those studies do not appear to inform the present case. See exhibit B at 4 (citing, e.g., exhibit O (Nizar Souayah et al., Analysis of Data from the CDC/FDA Vaccine Adverse Event Reporting System (1990-2009) on Guillain-Barre Syndrome after Hepatitis Vaccination in the USA, 19 J. Clinical Neuroscience 1089 (2012)) and exhibit U (Penina Haber et al., Vaccines and Guillain-Barré Syndrome, 32 Drug Safety 309 (2009)). As noted above, Dr. Gershwin does not claim that the hepatitis vaccine alone caused Mr. Eamick’s GBS to develop. Instead, Dr. Gershwin argues that the vaccination explains why Mr. Eamick’s URI induced a loss of tolerance, something that very few URIs do. An informative epidemiological study would have to examine the effects of hepatitis vaccination on individuals suffering from a URI (or perhaps other infections associated with GBS) to see if there were an increased risk of developing GBS. According to both experts, these studies have not been done and would be incredibly difficult to do given the sample size required. Tr. 97, 211. Dr. Morel also challenges Dr. Gershwin’s theory on the basis that there is a lack of evidence linking hepatitis vaccinations with GBS. However, it appears that she applies a burden that is in excess of the burden imagined by the Vaccine Act as interpreted by the Federal Circuit. Towards the end of her testimony, Dr. Morel summarized her opinion: . . . there aren't any studies that have -- that describe the precise sequence of events that Mr. Eamick went through. All we can say is that, taken separately, we know that GBS is usually preceded by an upper respiratory tract infection and that hepatitis A and B vaccines, in general, do not cause that disease. So I think I'd just put those two facts together, and that's how I came up with my opinion. Tr. 243. This statement reflects the undersigned’s general impression that Dr. Morel and Dr. Gershwin primarily disagree about the sufficiency of the evidence necessary to draw their conclusions. As a physician and a scientist, Dr. Morel may find the evidence here to be insufficient to conclude that the hepatitis vaccinations can cause GBS under the right circumstances. However, the undersigned is not tasked with determining if the hepatitis vaccinations can cause GBS with anything approaching medical certainty. The only question is whether petitioner’s theory meets the standards set forth by the Federal Circuit under Althen. On its face, Dr. Gershwin’s theory is persuasive. Respondent has presented insufficient evidence 9 Case 1:15-vv-00519-UNJ Document 73 Filed 06/12/18 Page 10 of 13 to undermine its reputability and thus Mr. Eamick has satisfied the first prong of the Althen analysis. B. Althen Prong Three: Temporal Relationship between the Vaccination and the Injury. Neither party focused on the issue of timing. Petitioner’s pre-hearing brief dedicated a paragraph to the issue. See Pet’r’s Preh’g Br., filed June 13, 2017, at 22. Respondent’s brief dedicated two. See Resp’t’s Preh’g Br., filed July 13, 2017, at 17. However, the extent of respondent’s argument was to say that petitioner did not sufficiently address the timing element. Id. The limited time spent analyzing the question of timing is likely, in part, attributable to the fact that both parties agree that the timing between Mr. Eamick’s URI and the onset of his GBS was consistent with a causal link existing between the two. Id. This fact is, in large part, the basis for the Secretary’s argument that the URI completely accounts for Mr. Eamick’s GBS. See Tr. 183; see also exhibit B at 3 (noting that the timing was appropriate). However, as noted before, the point of disagreement between the parties is whether the vaccination was also a substantial factor. See Shyface v. Secʼy of Health & Human Servs., 165 F.3d 1344, 1352 (Fed. Cir. 1999) (indicating that a vaccination is the “legal cause” of an injury if the vaccination “is a ‘substantial factor’ in bringing about the harm, and that the harm would not have occurred but for the” vaccination). In his testimony, Dr. Gershwin points to the timing between the vaccination and the onset of GBS as indicating a causal relationship between the two. To support this assertion, Dr. Gershwin explained that starting 24-48 hours after antigen exposure, immunoglobulin (Ig) that has been exposed to the antigen will begin to “class switch” from IgM to IgG. Tr. 100. This class switch would peak seven to ten days following antigen presentation. Id. This change to IgG is important because IgG can more easily pass through the blood brain barrier and result in the type of pathology seen in GBS. Tr. 199. Because Mr. Eamick’s GBS symptoms appeared one week following his vaccination, Dr. Gershwin argues that this sequence is consistent with his medical theory that the cytokine response to the hepatitis vaccine played a substantial role in the development of Mr. Eamick’s GBS. Tr. 100. The respondent’s expert did not counter this argument. Accordingly, the evidence in the record favors a finding that there was an 10 Case 1:15-vv-00519-UNJ Document 73 Filed 06/12/18 Page 11 of 13 appropriately proximate temporal relationship between the vaccination and the onset of Mr. Eamick’s GBS. C. Althen Prong Two: Logical Sequence of Cause and Effect Showing that the Vaccination was the Reason for Mr. Eamick’s GBS. Evidence of a viable medical theory and temporal proximity between the vaccination and the injury is strong evidence of causation. However, the Federal Circuit has also said that such evidence is not enough. Althen, 418 F.3d at 1278 (“[a]lthough probative, neither a mere showing of a proximate temporal relationship between vaccination and injury, nor a simplistic elimination of other potential causes of the injury suffices, without more, to meet the burden of showing actual causation”). In Capizzano, the Federal Circuit further expounded upon the importance of evaluating whether a logical sequence of cause and effect exists independently of the timing analysis. Specifically, the Capizzano panel stated “[t]here may well be a circumstance where it is found that a vaccine can cause the injury at issue and where the injury was temporally proximate to the vaccination, but it is illogical to conclude that the injury was actually caused by the vaccine.” Capizzano, 440 F.3d at 1327. Thus, special masters must consider the whole picture and determine, on the basis of all the evidence, if the purported connection between the vaccination and the injury is logical. Examples of some of the evidence that special masters may consider here include the opinions of treating physicians and medical experts, evidence of rechallenge, epidemiological studies, and the probability of coincidence or another cause. See id. The evidence available to be weighed will, of course, depend on the facts of the case. The parties did not present much evidence to be weighed under the second Althen Prong. See Pet’r’s Preh’g Br., filed June 13, 2017, at 20-22; Resp’t’s Preh’g Br., filed July 13, 2017, at 15-17. In large part, the focus of both petitioner’s and respondent’s arguments under this prong of the analysis reverted to an examination of the underlying medical theory as well as the temporal relationship between the URI, the vaccinations, and the GBS. Id. These issues have been reviewed above. In addition, respondent points out that no treating physician associated Mr. Eamick’s GBS to his vaccinations. Resp’t’s Preh’g Br., filed July 13, 2017, at 15; Tr. 125. While this observation weighs against the conclusion that there exists a logical connection between the vaccinations and the disease, the weight of this evidence is not substantial. For one, as reviewed above, it is unknown why some URIs trigger GBS and others do not. Accordingly, the physician would merely be 11 Case 1:15-vv-00519-UNJ Document 73 Filed 06/12/18 Page 12 of 13 speculating and this lack of speculation in the medical records does not strike the undersigned as particularly meaningful. Second, Dr. Gershwin’s opinion that the association between Mr. Eamick’s vaccination and his development of GBS is logical is given substantial weight. As noted before, Dr. Gershwin’s testimony was particularly credible and his argument for the logical basis between the vaccination and the injury was persuasive. See Section II.C. D. Alternative Causation or Factor Unrelated Even though Mr. Eamick has established his prima facie case under Althen, the Secretary may still establish by preponderant evidence that his GBS is due to factors unrelated to the vaccinations, thus precluding compensation. See Deribeaux v. Sec'y of Health & Human Servs., 717 F.3d 1363, 1367 (Fed. Cir. 2013) (citing 42 U.S.C. § 300aa–13(a)(1)(B)). To do so, respondent must “provide that proof by identifying a particular such factor (or factors) and presenting sufficient evidence to establish that it was the sole substantial factor in bringing about the injury.” Bazan v. Sec'y of Health & Human Servs., 539 F.3d 1347, 1354 (Fed. Cir. 2008). Here, the Secretary argues that Mr. Eamick’s URI is the sole substantial factor in bringing about his GBS and that this should preclude compensation. Resp’t’s Preh’g Br., filed July 13, 2017, at 10, 16. In doing so, respondent cites to Tompkins v. Sec'y of Health & Human Servs., No. 10-261V, 2013 WL 3498652 (Fed. Cl. Spec. Mstr. June 21, 2013), mot. for rev. denied, 117 Fed. Cl. 713 (2014). The respondent is correct in noting that the facts in Tompkins are quite similar to the facts of Mr. Eamick’s case. Thus, it is not surprising that the respondent points to Special Master Vowell’s conclusion that Mr. Tompkins’s preceding respiratory infection was the cause of his GBS, precluding compensation. Id. at *1 (“I find that his upper respiratory infection, which began two weeks prior to the onset of his GBS symptoms, is a well-recognized cause of GBS, occurred at an appropriate temporal interval before onset of symptoms, and is the most likely cause for [petitioner’s] GBS”). As a preliminary note, “[i]t is well-settled that special masters are neither bound by their own decisions nor by cases from the Court of Federal Claims . . . .” Rickett v. Sec'y of Health & Human Servs., 468 F. App'x 952, 959 (Fed. Cir. 2011) (citing Hanlon v. Sec'y of Health & Human Servs., 40 Fed. Cl. 625, 630 (1998), aff'd, 191 F.3d 1344 (Fed. Cir. 1999)). Furthermore, the Federal Circuit has explicitly noted that special masters may very well come to different conclusions based on the same set of facts. Lampe v. Sec'y of Health & Human Servs., 219 12 Case 1:15-vv-00519-UNJ Document 73 Filed 06/12/18 Page 13 of 13 F.3d 1357, 1368 (Fed. Cir. 2000). But of course, the facts here, though similar, are not identical. For example, Mr. Eamick relied upon a different expert — one that, as stated in Section II, made a persuasive case in support of Mr. Eamick’s claim. But, even more, Mr. Eamick did not rely on the same theory proffered by Mr. Tompkins. As reviewed in Section IV.A, above, petitioner does not dispute that the URI was necessary for Mr. Eamick’s GBS to develop. He does dispute, however, that it was sufficient. Mr. Eamick supports this assertion by demonstrating that the vast majority of URIs do not develop into GBS and that it is currently believed that host factors, and not the preceding infection itself, are critical in determining whether a URI will cause GBS. See exhibit 51 (Hadden) at 7. Dr. Gershwin proposes a cytokine response to hepatitis vaccination as constituting this host factor in Mr. Eamick’s case and, for the reasons stated above, this explanation appears persuasive. Based on the evidence in the record, it does not appear that the respondent presents an alternate explanation for why Mr. Eamick’s URI caused the onset of his GBS when the vast majority of URIs do not. While it may be true that most cases of GBS are preceded by an infection, it is not true that most infections are followed by GBS. Clearly, there is more to the story. In this way, the absence of an alternate host factor that may have induced the onset of GBS in Mr. Eamick’s case actually weighs in petitioner’s favor. V. Conclusion As the Federal Circuit has noted, cases in the Vaccine Program often have to navigate an area of science bereft of certainty and absolutes. We, as a society, can only hope to one day know why Mr. Eamick developed GBS, and a particularly virulent form of the disease at that. Until that time, the Federal Circuit has stated that compensation is appropriate when a petitioner can provide evidence of a reputable medical theory attributing petitioner’s injury to the vaccination, evidence of an appropriately proximate temporal relationship between the two, and evidence that the causal association is logical. Mr. Eamick has met this standard and, therefore, is entitled to compensation under the Vaccine Act. An order regarding damages will be issued shortly. s/ Christian J. Moran Christian J. Moran Special Master 13 ================================================================================ DOCUMENT 2: USCOURTS-cofc-1_15-vv-00519-1 Date issued/filed: 2019-07-24 Pages: 9 Docket text: PUBLIC DECISION (Originally filed: 6/26/2019) regarding 87 DECISION of Special Master. Signed by Special Master Christian J. Moran. (abs) Service on parties made. -------------------------------------------------------------------------------- Case 1:15-vv-00519-UNJ Document 91 Filed 07/24/19 Page 1 of 9 In the United States Court of Federal Claims OFFICE OF SPECIAL MASTERS * * * * * * * * * * * * * * * * * * * * * JEREMY EAMICK, * No. 15-519V * Special Master Christian J. Moran Petitioner, * * v. * Filed: June 26, 2019 * SECRETARY OF HEALTH * Damages; hepatitis A vaccine; AND HUMAN SERVICES, * hepatitis B vaccine; Miller-Fisher; * Guillain-Barré syndrome (“GBS”) Respondent. * * * * * * * * * * * * * * * * * * * * * * Edward M, Kraus, Law Offices of Chicago Kent, Chicago, IL, for Petitioner; Lisa Ann Watts, U.S. Department of Justice, Washington, DC, for Respondent. UNPUBLISHED DECISION AWARDING DAMAGES1 On May 21, 2015, Jeremy Eamick filed a petition seeking compensation under the National Vaccine Injury Compensation Program, 42 U.S.C. §§ 300aa–1 through 34, alleging that the hepatitis A, hepatitis B, meningococcal, and tetanus- diphtheria-pertussis vaccines caused him to suffer the Miller-Fisher variant of Guillain-Barré syndrome (“GBS”). Following an entitlement hearing, on May 15, 2018, the undersigned ruled that Mr. Eamick is entitled to compensation under the Vaccine Act for his GBS injury due to the hepatitis A and B vaccines. Ruling, 2018 WL 2926048. On June 24, 2019, respondent filed a Proffer on Award of Compensation, to which petitioner agrees. Based upon the record as a whole, the special master finds the proffer reasonable and that petitioner is entitled to an award of life care 1 The E-Government Act, 44 § 3501 note (2012) (Federal Management and Promotion of Electronic Government Services), requires that the Court post this decision on its website. Pursuant to Vaccine Rule 18(b), the parties have 14 days to file a motion proposing redaction of medical information or other information described in 42 U.S.C. § 300aa-12(d)(4). Any redactions ordered by the special master will appear in the document posted on the website. Case 1:15-vv-00519-UNJ Document 91 Filed 07/24/19 Page 2 of 9 items, lost earnings, pain and suffering damages, and past unreimbursable expenses as stated in the Proffer. Pursuant to the attached Proffer, the following is awarded to petitioner: A. A lump sum payment of $1,217,984.83 representing compensation for life care expenses expected to be incurred during the first year after judgment ($17,522.35), lost earnings ($950,125.39), pain and suffering ($250,000.00), and past unreimbursable expenses ($337.09), in the form of a check payable to petitioner, Jeremy Eamick. B. An amount sufficient to purchase an annuity contract, subject to the conditions described in the proffer, that will provide payments for the life care items contained in the life care plan attached to the proffer. These payments represent compensation for all damages that would be available under 42 U.S.C. §300aa-15(a). In the absence of a motion for review filed pursuant to RCFC, Appendix B, the clerk is directed to enter judgment in case 15-519V according to this decision and the attached proffer.2 Any questions may be directed to my law clerk, Andrew Schick, at (202) 357-6360. IT IS SO ORDERED. s/Christian J. Moran Christian J. Moran Special Master 2 Pursuant to Vaccine Rule 11(a), the parties can expedite entry of judgment by each party filing a notice renouncing the right to seek review by a United States Court of Federal Claims judge. Case 1:15-vv-00519-UNJ Document 91 Filed 07/24/19 Page 3 of 9 IN THE UNITED STATES COURT OF FEDERAL CLAIMS OFFICE OF SPECIAL MASTERS JEREMY EAMICK, Petitioner, v. No. 15-519V Special Master Moran SECRETARY OF HEALTH AND ECF HUMAN SERVICES, Respondent. RESPONDENT'S PROFFER ON AWARD OF COMPENSATION In his Ruling on Entitlement issued on May 15, 2018, the Special Master found that a preponderance of the evidence supported Jeremy Eamick’s (“petitioner’s”) claim that hepatitis A and hepatitis B vaccines administered to him on July 17, 2012, caused his Miller-Fisher variant of Guillain-Barré syndrome. Respondent now Proffers the following regarding the amount of compensation to be awarded.1 I. Items of Compensation A. Life Care Items Respondent engaged life care planner Linda Curtis, RN, MS, CCM, CNLCP, and petitioner engaged Susan Guth, LCSW, CCM, CLCP, to provide an estimation of petitioner’s future vaccine-injury related needs. For the purposes of this proffer, the term “vaccine-related” is as described in the Special Master’s Ruling on Entitlement. All items of compensation identified in the life care plan are supported by the evidence, and are illustrated by the chart entitled “Appendix A: Items of Compensation for Jeremy Eamick,” attached hereto as Appendix 1 The parties have no objection to the proffered award of damages. However, respondent reserves his right to seek review of the Special Master’s decision pursuant to 42 U.S.C. § 300aa- 12(e)(1). -1- Case 1:15-vv-00519-UNJ Document 91 Filed 07/24/19 Page 4 of 9 A.2 Respondent proffers that petitioner should be awarded all items of compensation set forth in the life care plan and illustrated by the chart attached as Appendix A. Petitioner agrees. B. Lost Earnings The parties agree that based upon the evidence of record, Jeremy Eamick has suffered past loss of earnings and will suffer a loss of earnings in the future due to his vaccine-related injuries. Therefore, respondent proffers that Jeremy Eamick should be awarded lost earnings as provided under the Vaccine Act, 42 U.S.C. § 300aa-15(a)(3)(A). Respondent proffers that the appropriate award for Jeremy Eamick’s lost earnings is $950,125.39. Petitioner agrees. C. Pain and Suffering Respondent proffers that Jeremy Eamick should be awarded $250,000.00 in actual and projected pain and suffering. This amount reflects that any award for projected pain and suffering has been reduced to net present value. See 42 U.S.C. § 300aa-15(a)(4). Petitioner agrees. D. Past Unreimbursable Expenses Evidence supplied by petitioner documents his expenditure of past unreimbursable expenses related to his vaccine-related injuries. Respondent proffers that petitioner should be awarded past unreimbursable expenses in the amount of $337.09. II. Form of the Award The parties recommend that the compensation provided to petitioner should be made through a combination of lump sum payments and future annuity payments as described below, and request that the Special Master’s decision and the Court’s judgment award the following:3 2 The chart at Appendix A illustrates the annual benefits provided by the life care plan. The annual benefit years run from the date of judgment up to the first anniversary of the date of judgment, and every year thereafter up to the anniversary of the date of judgment. -2- Case 1:15-vv-00519-UNJ Document 91 Filed 07/24/19 Page 5 of 9 A. A lump sum payment of $1,217,984.83, representing compensation for life care expenses expected to be incurred during the first year after judgment ($17,522.35), lost earnings ($950,125.39), pain and suffering ($250,000.00), and past unreimbursable expenses ($337.09), in the form of a check payable to petitioner, Jeremy Eamick. B. An amount sufficient to purchase an annuity contract,4 subject to the conditions described below, that will provide payments for the life care items contained in the life care plan, as illustrated by the chart at Appendix A, attached hereto, paid to the life insurance company5 from which the annuity will be purchased.6 Compensation for Year Two (beginning on the first anniversary of the date of judgment) and all subsequent years shall be provided through respondent’s purchase of an annuity, which annuity shall make payments directly to petitioner, Jeremy Eamick, only so long as Jeremy Eamick is alive at the time a particular payment is due. At the Secretary’s sole discretion, the periodic payments may be provided to petitioner in 3 Should petitioner die prior to entry of judgment, the parties reserve the right to move the Court for appropriate relief. In particular, respondent would oppose any award for future medical expenses, future lost earnings, and future pain and suffering. 4 In respondent’s discretion, respondent may purchase one or more annuity contracts from one or more life insurance companies. 5 The Life Insurance Company must have a minimum of $250,000,000 capital and surplus, exclusive of any mandatory security valuation reserve. The Life Insurance Company must have one of the following ratings from two of the following rating organizations: a. A.M. Best Company: A++, A+, A+g, A+p, A+r, or A+s; b. Moody's Investor Service Claims Paying Rating: Aa3, Aa2, Aa1, or Aaa; c. Standard and Poor's Corporation Insurer Claims-Paying Ability Rating: AA-, AA, AA+, or AAA; d. Fitch Credit Rating Company, Insurance Company Claims Paying Ability Rating: AA-, AA, AA+, or AAA. 6 Petitioner authorizes the disclosure of certain documents filed by the petitioner in this case consistent with the Privacy Act and the routine uses described in the National Vaccine Injury Compensation Program System of Records, No. 09-15-0056. -3- Case 1:15-vv-00519-UNJ Document 91 Filed 07/24/19 Page 6 of 9 monthly, quarterly, annual or other installments. The “annual amounts” set forth in the chart at Appendix A describe only the total yearly sum to be paid to petitioner and do not require that the payment be made in one annual installment. 1. Growth Rate Respondent proffers that a four percent (4%) growth rate should be applied to all non- medical life care items, and a five percent (5%) growth rate should be applied to all medical life care items. Thus, the benefits illustrated in the chart at Appendix A that are to be paid through annuity payments should grow as follows: four percent (4%) compounded annually from the date of judgment for non-medical items, and five percent (5%) compounded annually from the date of judgment for medical items. Petitioner agrees. 2. Life-contingent annuity Petitioner will continue to receive the annuity payments from the Life Insurance Company only so long as he, Jeremy Eamick, is alive at the time that a particular payment is due. Written notice shall be provided to the Secretary of Health and Human Services and the Life Insurance Company within twenty (20) days of Jeremy Eamick’s death. 3. Guardianship Petitioner is a competent adult. Evidence of guardianship is not required in this case. III. Summary of Recommended Payments Following Judgment A. Lump Sum paid to petitioner, Jeremy Eamick: $1,217,984.83 B. An amount sufficient to purchase the annuity contract described above in section II.B. Respectfully submitted, JOSEPH H. HUNT Assistant Attorney General -4- Case 1:15-vv-00519-UNJ Document 91 Filed 07/24/19 Page 7 of 9 C. SALVATORE D’ALESSIO Acting Director Torts Branch, Civil Division CATHARINE E. REEVES Deputy Director Torts Branch, Civil Division HEATHER L. PEARLMAN Assistant Director Torts Branch, Civil Division /s/LISA A. WATTS LISA A. WATTS Senior Trial Attorney Torts Branch, Civil Division U. S. Department of Justice P.O. Box l46, Benjamin Franklin Station Washington, D.C. 20044-0146 Direct dial: (202) 616-4099 Dated: June 24, 2019 -5- Case 1:15-vv-00519-UNJ Document 91 Filed 07/24/19 Page 8 of 9 Appendix A: Items of Compensation for Jeremy Eamick Page 1 of 2 Lump Sum Compensation Compensation Compensation Compensation Compensation Compensation ITEMS OF COMPENSATION G.R. * M Year 1 Years 2-15 Year 16 Years 17-25 Years 26-33 Years 34-Life 2019 2020-2033 2034 2035-2043 2044-2051 2052-Life Tricare Deductible 5% 150.00 150.00 150.00 150.00 150.00 150.00 Medicare Part B Premium 5% M 1,626.00 1,626.00 1,626.00 1,626.00 Primary Care Physician 5% * Mileage: Primary Care Physician 4% 1.08 1.08 1.08 1.08 1.08 1.08 Neurology 5% Mileage: Neurology 4% 15.20 15.20 15.20 15.20 15.20 15.20 Pain Management 5% * Mileage: Pain Management 4% 29.12 29.12 29.12 29.12 29.12 29.12 Physiatry 4% * Mileage: Physiatry 4% 3.48 3.48 3.48 3.48 3.48 3.48 Counseling 4% * Mileage: Counseling 4% 68.88 Care Management 4% M 1,110.00 1,110.00 1,110.00 1,110.00 1,110.00 1,110.00 Gabapentin 5% * Metho-carbamol 5% * Wellbutrin 5% * Naproxen 5% * Pravastatin 5% * Hydrochlorothiazide 5% * Walker 4% 76.99 15.40 15.40 15.40 15.40 15.40 Manual Wheelchair 4% 225.00 22.50 22.50 22.50 22.50 22.50 Walking Sticks 4% 59.98 12.00 12.00 12.00 12.00 12.00 Knee Brace 4% 43.98 43.98 43.98 43.98 43.98 43.98 Elbow Brace 4% 33.98 33.98 33.98 33.98 33.98 33.98 Knee Ice Wrap 4% 59.40 19.80 19.80 19.80 19.80 19.80 Low Back Ice Wrap 4% 59.99 20.00 20.00 20.00 20.00 20.00 Heating Pad 4% 23.98 4.80 4.80 4.80 4.80 4.80 Shower Chair 4% 28.87 5.77 5.77 5.77 5.77 5.77 Reacher 4% 55.40 9.23 9.23 9.23 9.23 9.23 Dressing Aid 4% 39.50 6.58 6.58 6.58 6.58 6.58 Scooter 4% 1,635.00 163.50 163.50 163.50 Case 1:15-vv-00519-UNJ Document 91 Filed 07/24/19 Page 9 of 9 Appendix A: Items of Compensation for Jeremy Eamick Page 2 of 2 Lump Sum Compensation Compensation Compensation Compensation Compensation Compensation ITEMS OF COMPENSATION G.R. * M Year 1 Years 2-15 Year 16 Years 17-25 Years 26-33 Years 34-Life 2019 2020-2033 2034 2035-2043 2044-2051 2052-Life Scooter Batteries 4% 99.98 99.98 99.98 99.98 Physical Therapy Evaluation 4% * Mileage: Physical Therapy Evaluation 4% 1.04 1.04 1.04 1.04 1.04 1.04 Physical Therapy 4% * Mileage: Physical Therapy 4% 12.48 2.50 2.50 2.50 2.50 2.50 YMCA 4% 762.00 762.00 762.00 762.00 Companion Care/Personal Care Att. 4% M 6,864.00 6,864.00 6,864.00 6,864.00 16,425.00 16,425.00 Ancillary Services 4% M 1,824.00 1,824.00 1,824.00 1,824.00 1,824.00 1,824.00 Ancillary Services 4% M 1,848.00 1,848.00 1,848.00 1,848.00 1,848.00 Chair Lift 4% 2,500.00 Scooter Car Carrier 4% 1,294.99 129.50 129.50 129.50 Lost Earnings 950,125.39 Pain and Suffering 250,000.00 Past Unreimbursable Expenses 337.09 Annual Totals 1,217,984.83 14,430.46 17,460.43 14,823.44 21,996.44 20,148.44 Note: Compensation Year 1 consists of the 12 month period following the date of judgment. Compensation Year 2 consists of the 12 month period commencing on the first anniversary of the date of judgment. As soon as practicable after entry of judgment, respondent shall make the following payment to petitioner for Yr 1 life care expenses ($17,522.35), lost earnings ($950,125.39), pain and suffering ($250,000.00), and past unreimbursable expenses ($337.09): $1,217,984.83. Annual amounts payable through an annuity for future Compensation Years follow the anniversary of the date of judgment. Annual amounts shall increase at the rates indicated above in column G.R., compounded annually from the date of judgment. Items denoted with an asterisk (*) covered by health insurance and/or Medicare. Items denoted with an "M" payable in twelve monthly installments totaling the annual amount indicated.